Substance assessment · Regulatory compliance

All the toxicological and regulatory evidence, ready before your signature.

Nippurity pre-fills, accelerates and leaves a trace of the assessment of substances, ingredients and formulations. The numbers are deterministic; the AI explains and cites them. The signature —and the responsibility— stay with the Safety Assessor (Art. 10).

  • 43,000+ regulatory records indexed
  • 11 toxicological endpoints (Annex I)
  • 4 languages · es · it · pt · en
  • Multi-industry
  • Cosmetics flagship
  • Regulation (EC) 1223/2009
The corpus, in numbers

Living regulation, real coverage.

We don't promise a universe of data: we have it indexed, dated and audited. These are the figures behind every assessment.

regulatory records indexed

Consolidated corpus · 5 live sources

43,837 real records behind the 43,000+ — we round down, never the other way.

  • COSING ingredients

    European inventory of cosmetic ingredients

  • CLP / CMR substances

    Classified carcinogens, mutagens and reprotoxicants

  • EUR-Lex entries

    Annexes of Regulation (EC) 1223/2009

11 toxicological endpoints · 2 QSAR engines (Toxtree, OPERA) · 4 languages (es · it · pt · en)

Capability 01 · Toxicological assessment

Eleven Annex I endpoints, each with its maturity in plain sight.

Nippurity orchestrates open QSAR engines to pre-fill the Annex I toxicological assessment. Every endpoint arrives with its maturity level declared: you know how much it weighs before you rely on it.

  • Maturity declared per endpoint Defensible, screening or alert. The level travels with the result; never a black box.
  • Orchestrated open QSAR engines Toxtree and OPERA/CATMoS coordinated, with provenance traceability for every prediction.
  • “Not assessed” when there is no engine Whatever no engine covers is flagged as such — methodological honesty, not padding.
  • Expert judgement stays yours Nippurity pre-fills and accelerates; the Safety Assessor reviews, adjusts and decides.
11 Annex I toxicological endpoints

2 orchestrated open QSAR engines — Toxtree, OPERA/CATMoS

Endpoint matrix Each graph node lights up with its endpoint's maturity.
  • ADME Toxicokinetics (ADME)
  • ATA Acute toxicity
  • IRR Skin irritation / corrosion
  • OCU Eye damage
  • SENS Skin sensitisation
  • DRA Repeated-dose toxicity
  • MUT Mutagenicity / genotoxicity
  • CAR Carcinogenicity
  • REP Reproductive toxicity
  • TK Dermal toxicokinetics
  • PHO Phototoxicity
  • Defensible
  • Screening
  • Alert
  • Not assessed

No invented colour: methodological honesty is a visible feature, not a disclaimer.

Changes detected Monitoring
Critical EUR-Lex · Annex II

Butylphenyl methylpropional (Lilial)

Previous version Allowed with concentration restriction
Current version Banned — added to the list of prohibited substances

Impact on your portfolio 3 formulations affected

  • High Octamethylcyclotetrasiloxane (D4) ECHA SVHC 1 ingredient under review
  • Medium Titanium dioxide (powder form) CLP / CMR Review 2 technical sheets

Capability 02 · Regulatory monitoring

It stays in sync so you don't have to chase the change.

Regulation moves without warning. Nippurity watches the live sources, detects the diff between versions and alerts you by severity — with the exact impact on the substances in your portfolio.

5 live sources, monitored continuously
  • COSING
  • EUR-Lex · Annexes II–VI
  • CLP / CMR
  • ECHA SVHC
  • SCCS
  • A diff between versions, not just an alert

    You see what the rule said before and what it says now, side by side. The change reads at a glance, not buried in an 80-page PDF.

  • Severity-based alerts

    Critical, high, medium or low. You know what to act on today and what can wait, without treating every change as an emergency.

  • Impact on your portfolio

    Every alert is cross-referenced with your substances and formulations. It isn't «the law changed», it's «these 3 formulas of yours need your attention».

43,000+ regulatory records indexed
5 live sources monitored

It watches while you sleep. You decide when to act.

Restricted origin Butylphenyl Methylpropional INCI · Lilial Banned as CMR 1B Annex II, entry 1666 — Regulation (EC) 1223/2009
Proposed candidate Florhydral INCI · 3-(p-Isopropylphenyl)propionaldehyde Defensible
Regulatory rationale

Florhydral has no Annex II entry and no CMR classification; it shares the aromatic aldehyde that carries the original's olfactory character and clears deterministic screening against live sources.

COSING · EUR-Lex Annexes II–VI · CLP/CMR — checked against the version in force
Capability 03 · Substitute search

When a substance falls, you already know where to go next.

For banned or restricted ingredients, Nippurity proposes viable candidates, ranks them by structural similarity to the original and explains the why of each: deterministic regulatory screening and a cited rationale that the AI writes.

  1. 1
    Deterministic screening Filtered against live regulatory sources: nothing proposed without verifying its status.
  2. 2
    Structural similarity A molecular fingerprint (Morgan/ECFP4) and the Tanimoto index rank candidates by closeness to the original.
  3. 3
    AI that explains It writes and cites the why, over deterministic numbers.
  • Hydroxycitronellal Screening
    INCI · Hydroxycitronellal No CMR classification. Restricted as a declarable allergen (labelling threshold).
  • Florhydral Defensible
    INCI · 3-(p-Isopropylphenyl)propionaldehyde No Annex II entry. High structural similarity, deterministic screening cleared.
  • Cyclamen Aldehyde Alert
    INCI · Cyclamen Aldehyde Fragrance allergen subject to mandatory labelling. Similarity guides, but its threshold calls for expert review before deciding.

Deterministic screening + structural similarity + AI that explains the why

The AI writes and cites the rationale. The regulatory status and structural similarity are deterministic.

Capability 04 · CPSR report

The report reproduces; the signature is yours.

The Cosmetic Product Safety Report, Part A, comes out deterministic and dual-audience. Nippurity pre-fills it and gets it ready; the Safety Assessor reviews, decides and signs.

sha256 fingerprint of the canonical document
9f2c1a7e4b8d6035c1f0a93e7d24b6e8a05c3f19d847be20f6a1c93d8e72b4f0

Reproducible bit for bit: same input, same hash, no wall clock. Regenerate the report tomorrow and you get exactly the same fingerprint.

  • Deterministic and reproducible

    Every report is sealed with a sha256 hash over its canonical document. No timestamps: the same dossier always yields the same result.

  • Dual audience

    A technical write-up for the assessor and a clear one for the authority and the responsible person, without losing rigour in either.

  • Signed by a human

    Nippurity facilitates, pre-fills and accelerates. The legal responsibility and the signature remain the Safety Assessor's (Art. 10 of Regulation (EC) 1223/2009).

Outputs
HTMLPDFJSON

Traceability runs from the molecule to the signed report, never breaking along the way.

The determinism boundary

Data computes. The AI explains it.

The numbers —predictions, regulatory status, exposure, concentrations— live in a deterministic DATA block built by each feature. The AI puts them into clear words and cites their source, always faithful to that data.

  • Reproducible bit for bit

    The report is sealed with a hash over its canonical document, with no wall clock. Regenerating it yields exactly the same result, verifiable by anyone.

    sha256 hash · no wall clock
  • Methodological honesty

    Every endpoint declares its maturity —defensible, screening or alert—. Whatever has no engine is marked “not assessed”, with full transparency.

    11 endpoints · maturity per endpoint
  • The signature is human

    Nippurity facilitates, pre-fills and accelerates. The Safety Assessor's responsibility and signature remain theirs. The tool does not sign.

    Art. 10 · Regulation (EC) 1223/2009

Rigour you can sign. Data computes, AI explains.

Live regulatory sources

Regulation that changes, constant synchronisation.

Five live official sources, read as an instrument panel. Each seal breathes: it pulses while up to date and logs its last synchronisation. The corpus is a living organism, not a stale snapshot.

  • COSING Live

    European inventory of cosmetic ingredients.

    36,900+ ingredients Synced 2 h ago
  • EUR-Lex Live

    Annexes II–VI of Regulation (EC) 1223/2009.

    2,400+ entries Synced 6 h ago
  • CLP / CMR Live

    Classification of carcinogens, mutagens and reprotoxicants.

    4,400+ substances Synced 4 h ago
  • ECHA SVHC Live

    Substances of Very High Concern (REACH).

    Candidate list Synced 1 day ago
  • SCCS Live

    Opinions of the Scientific Committee on Consumer Safety.

    Opinions corpus Synced 3 days ago

When the source changes, the diff reaches your portfolio. No chasing the change.

Closing

We'll walk you through it with your own cases.

Bring a real substance, ingredient or formulation and see how Nippurity pre-fills the toxicological and regulatory evidence, declares the maturity of each endpoint and keeps everything traceable. Whatever has no engine is marked “not assessed”, with full honesty.

  • No commitment
  • With your real cases
  • Reproducible bit for bit · sha256 hash

The judgement is yours. The traceability is on us.